XNKQ Acupuncture Compared to Control Interventions Measured With EEG and fMRI

Completed

Phase N/A Results N/A

Trial Description

The investigators will use EEG, structural MRI, and resting-state functional connectivity MRI to assess neuronal responses in 28 healthy subjects to different somatosensory stimulations.

Detailed Description

To develop a better understanding of the cerebral response to a complex somatosensory intervention with XNKQ acupuncture and to build a foundation for future studies with stroke patients our study aims to evaluate changes of brain activity and brain structure in healthy subjects after XNKQ acupuncture in comparison to three control interventions. We will use EEG, structural MRI, and resting-state functional connectivity MRI to assess neuronal responses in 28 healthy subjects to a) strong manual needle-stimulation of the acupuncture points DU26, PC6 and SP6 (XNKQ acupuncture), b) insertion of needles on the acupuncture points DU26, PC6 and SP6 without stimulation (control 1), c) strong manual needle stimulation of three non-acupuncture points (control 2), and d) insertion of needles on three non-acupuncture points without stimulation (control 3). With this, our study aims to create results which inform future studies in patients and might be helpful for the rehabilitation of deficits after stroke.

Conditions

Interventions

  • XNKQ Other
    Intervention Desc: stimulation at 5 acupuncture points according to XNKQ acupuncture
    ARM 1: Kind: Experimental
    Label: healty subjects
    Description: they receive XNKQ acupuncture, as well as control 1, control 2, and control 3 in a randomized order.
    ARM 2: Kind: Experimental
    Label: healthy subjects
    Description: they receive XNKQ acupuncture, as well as control 1, control 2, and control 3 in a randomized order.
  • Control 1 Other
    Intervention Desc: no stimulation at 5 acupuncture points according to XNKQ acupuncture
    ARM 1: Kind: Experimental
    Label: healty subjects
    Description: they receive XNKQ acupuncture, as well as control 1, control 2, and control 3 in a randomized order.
    ARM 2: Kind: Experimental
    Label: healthy subjects
    Description: they receive XNKQ acupuncture, as well as control 1, control 2, and control 3 in a randomized order.
  • Control 2 Other
    Intervention Desc: stimulation at 5 control points
    ARM 1: Kind: Experimental
    Label: healty subjects
    Description: they receive XNKQ acupuncture, as well as control 1, control 2, and control 3 in a randomized order.
    ARM 2: Kind: Experimental
    Label: healthy subjects
    Description: they receive XNKQ acupuncture, as well as control 1, control 2, and control 3 in a randomized order.
  • Control 3 Other
    Intervention Desc: no stimulation at 5 control points
    ARM 1: Kind: Experimental
    Label: healty subjects
    Description: they receive XNKQ acupuncture, as well as control 1, control 2, and control 3 in a randomized order.
    ARM 2: Kind: Experimental
    Label: healthy subjects
    Description: they receive XNKQ acupuncture, as well as control 1, control 2, and control 3 in a randomized order.

Trial Design

  • Allocation: Randomized
  • Masking: Single Blind (Subject)
  • Purpose: Basic Science
  • Intervention: Factorial Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Change in brain background rhythms (mu-alpha and beta activity) [assessed using EEG and MRI] after one intervention (baseline vs. post stimulation) in comparison between the four different interventions. 60 minutes No
Primary Changes in resting state functional connectivity [assessed using EEG and MRI] after one intervention (baseline vs. post-stimulation) in comparison between the four different interventions 60 minutes No

Sponsors