Warfarin Versus Aspirin in Patients With Atrial Fibrillation and Chronic Kidney Disease

Not yet recruiting

Phase 4 Results N/A

Trial Description

In this study, the investigators examine whether aspirin or warfarin is useful for atrial fibrillation patients with chronic kidney disease.

Detailed Description

randomised open labelled prospective study
We enroll patients with CHADS2 score 1 non-valvular AF with chronic kidney disease, and analyze all thromboembolic event or major bleeding event during follow-up period. Warfarin group take dose adjusted warfarin (target INR 2.0-3.0) and aspirin group take aspirin 100mg daly.
Thromboembolic events: Ischemic stroke or systemic arterial occlusion Major bleeding: gastrointestinal bleeding or intracranial bleeding (code 430, code 431, code 432 by ICD-9-CM codes)
-> Only the first event of each case will be used for the analysis

Conditions

Interventions

  • Warfarin (Coumadin┬«)Drug
    ARM 1: Kind: Experimental
    Label: warfarin
  • Aspirin Drug
    Other Names: Aspirin at bedtime
    ARM 1: Kind: Experimental
    Label: aspirin

Trial Design

  • Allocation: Randomized
  • Masking: Open Label
  • Purpose: Prevention
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Thromboembolic event
Secondary Major bleeding Yes

Sponsors