To compare the prophylactic efficacies of warfarin and aspirin against stroke and vascular death in patients with symptomatic stenosis of a major intracranial artery.
- Aspirin (stroke prevention) Drug
Intervention Desc: Antiplatelet agent; inhibits thromboxane A2
- Warfarin (Coumadin®)Drug
Other Names: Coumadin Intervention Desc: Anticoagulant (Vitamin K antagonist)
Prospective, double-blind, randomized, multi-center trial.
All participants must undergo conventional angiography to determine the degree af arterial stenosis. Eligible patients will be randomized to receive either aspirin 1300 mg/day or warfarin, titrated to an International Normalized Ratio (INR) of 2 - 3. All patients will receive monthly bloodtests, and will be evaluated by a neurologist every four months, until the end of the trial.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Incidence of ischemic stroke, hemorrhagic stroke, and vascular death.|
|Secondary||Incidence of vascular death and disabling stroke, all stroke, all ischemic stroke, myocardial infarction, major systemic hemorrhage, intracranial hemorrhage, and ischemic stroke in the territory of the stenotic intracranial artery.|