Visual Perceptual Learning for the Treatment of Visual Field Defect "VIVID"

Recruiting

Phase N/A Results N/A

Update History

12 Apr '14
The description was updated.
New
Study design: A PROBE (Prospective, Randomized, Open-label, Blinded-endpoint) design Methods: 1. Visual perceptual learning (VPL) group 1. Visual perceptual learning (24 times for 2 months, 3 times per week) in visual field defect areas 2. At baseline and post-VPL evaluations (2 months after): Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires 2. Control group 1. At baseline and 2-months later: No VPL, Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires 2. Visual perceptual learning after 2-month follow-up evaluation (24 times for 2 months, 3 times per week) (The patients who were stratified by age (over 65 years old or not) and degree of visual field defect (quadrantanopia or complete hemianopia) will be randomly assigned into the learning and control group.) 3. Investigations 1. Improvement of visual field test scores between VPL group and control group 2. Analysis of brain network changes in MRI data 3. Correlation analysis of improvement of visual field defect and MRI data 4. Correlation analysis of improvement of visual field defect and visual evoked potential (VEP) data 5. Correlation analysis of improvement of visual field defect and neuropsychological data
Old
Study design: A PROBE (Prospective, Randomized, Open-label, Blinded-endpoint) design Methods: 1. Visual perceptual learning (VPL) group 1. Visual perceptual learning (24 times for 2 months, 3 times per week) in visual field defect areas 2. At baseline and post-VPL evaluations (2 months after): Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires 2. Control group 1. At baseline and 2-months later: No VPL, Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires 2. Visual perceptual learning after 2-month follow-up evaluation (24 times for 2 months, 3 times per week) (The patients with incomplete hemianopia or quadrantanopia will be randomly assigned into the learning and control group. On the contrary, the patients with complete hemianopia will not be randomized and assigned into only learning group (single arm). We plan to investigate whether 2-month visual perceptual learning has any effects in the patients with complete hemianopia, because these patients showed poor responses to visual training in our prior evaluation.) 3. Investigations 1. Improvement of visual field test scores between VPL group and control group 2. Analysis of brain network changes in MRI data 3. Correlation analysis of improvement of visual field defect and MRI data 4. Correlation analysis of improvement of visual field defect and visual evoked potential (VEP) data 5. Correlation analysis of improvement of visual field defect and neuropsychological data
19 Mar '14
A location was updated in Seoul.
New
The overall status was updated to "Recruiting" at Asan Medical Center.
18 Dec '13
The description was updated.
New
Study design: A PROBE (Prospective, Randomized, Open-label, Blinded-endpoint) design Methods: 1. Visual perceptual learning (VPL) group 1. Visual perceptual learning (24 times for 2 months, 3 times per week) in visual field defect areas 2. At baseline and post-VPL evaluations (2 months after): Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires 2. Control group 1. At baseline and 2-months later: No VPL, Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires 2. Visual perceptual learning after 2-month follow-up evaluation (24 times for 2 months, 3 times per week) (The patients with incomplete hemianopia or quadrantanopia will be randomly assigned into the learning and control group. On the contrary, the patients with complete hemianopia will not be randomized and assigned into only learning group (single arm). We plan to investigate whether 2-month visual perceptual learning has any effects in the patients with complete hemianopia, because these patients showed poor responses to visual training in our prior evaluation.) 3. Investigations 1. Improvement of visual field test scores between VPL group and control group 2. Analysis of brain network changes in MRI data 3. Correlation analysis of improvement of visual field defect and MRI data 4. Correlation analysis of improvement of visual field defect and visual evoked potential (VEP) data 5. Correlation analysis of improvement of visual field defect and neuropsychological data
Old
Study design: A PROBE (Prospective, Randomized, Open-label, Blinded-endpoint) design Methods: 1. Visual perceptual learning (VPL) group 1. Visual perceptual learning (24 times for 2 months, 3 times per week) in visual field defect areas 2. At baseline and post-VPL evaluations (2 months after): Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires 2. Control group 1. At baseline and 2-months later: No VPL, Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires 2. Visual perceptual learning after 2-month follow-up evaluation (24 times for 2 months, 3 times per week) 3. Investigations 1. Improvement of visual field test scores between VPL group and control group 2. Analysis of brain network changes in MRI data 3. Correlation analysis of improvement of visual field defect and MRI data 4. Correlation analysis of improvement of visual field defect and visual evoked potential (VEP) data 5. Correlation analysis of improvement of visual field defect and neuropsychological data
7 Nov '13
The description was updated.
New
Study design: A PROBE (Prospective, Randomized, Open-label, Blinded-endpoint) design Methods: 1. Visual perceptual learning (VPL) group 1. Visual perceptual learning (24 times for 2 months, 3 times per week) in visual field defect areas 2. At baseline and post-VPL evaluations (2 months after): Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires 2. Control group 1. At baseline and 2-months later: No VPL, Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires 2. Visual perceptual learning after 2-month follow-up evaluation (24 times for 2 months, 3 times per week) 3. Investigations 1. Improvement of visual field test scores between VPL group and control group 2. Analysis of brain network changes in MRI data 3. Correlation analysis of improvement of visual field defect and MRI data 4. Correlation analysis of improvement of visual field defect and visual evoked potential (VEP) data 5. Correlation analysis of improvement of visual field defect and neuropsychological data
Old
Study design: A PROBE (Prospective, Randomized, Open-label, Blinded-endpoint) design Methods: 1. Visual perceptual learning (VPL) group 1. Visual perceptual learning (24 times for 2 months, 3 times per week) in visual field defect areas 2. At baseline and post-VPL evaluations (2 months after): Structural & Functional MRIs, Visual field tests, Visual cognitive tests, Subjective visual function questionnaires 2. Control group 1. At baseline and 2-months later: No VPL, Structural & Functional MRIs, Visual field tests, Visual cognitive tests, Subjective visual function questionnaires 2. Visual perceptual learning after 2-month follow-up evaluation (24 times for 2 months, 3 times per week) 3. Investigations 1. Improvement of visual field test scores between VPL group and control group 2. Analysis of brain network changes in MRI data 3. Correlation analysis of improvement of visual field defect and MRI data 4. Correlation analysis of improvement of visual field defect and neuropsychological data
The eligibility criteria were updated.
New
Inclusion Criteria: 1. The patient has chronic stroke more than 6 months after onset. 2. The patient has visual field defect (Quadrantanopia or Hemianopia). 3. The patient has corrected eyesight 0.7 or above. Exclusion Criteria: 1. The patient has contraindication to MRI scan. 2. The patient has cognitive impairment (Mini-Mental Status Exam score <24). 3. The patient has ophthalmologic diseases (e.g., glaucoma, cataract).
Old
Inclusion Criteria: 1. The patient has chronic stroke more than 6 months after onset. 2. The patient has visual field defect (Quadrantanopia or Hemianopia). Exclusion Criteria: 1. The patient has contraindication to MRI scan. 2. The patient has cognitive impairment (Mini-Mental Status Exam score <24).