Very Early Nimodipine Use in Stroke "VENUS"


Phase 3 Results

Trial Description

To prospectively study the effects of nimodipine administered early after stroke onset.


  • Nimodipine (NimotopĀ®)Drug
    Other Names: The treatment group
    Intervention Desc: Calcium channel blocker (L-type calcium channels)

Trial Design

Randomized. double-blind, placebo-controlled trial of 454 patients.

Patient Involvement

Patients were randomized to receive nimodipine 30 mg qid, po for 10 days or placebo.


Type Measure Time Frame Safety Issue
Primary All-cause mortality or dependency in daily life (Modified Rankin Scale score >3.11 ) 3 months after inclusion.
Secondary Neurological status and blood pressure 24 hours after inclusion, mortality after 10 days, and adverse events.


Dutch Prevention Fund. Medication supplied by Bayer AG.