Ventilation Strategies, Anesthetic Techniques and Cerebral Oxygenation in the Beach Chair Position

Completed

Phase N/A Results N/A

Update History

25 Sep '14
A location was updated in Ann Arbor.
New
The overall status was removed for University of Michigan.
19 Jul '13
A location was updated in Ann Arbor.
New
The overall status was removed for University of Michigan.
23 Aug '12
The description was updated.
New
This is a prospective cohort study with randomized nested design. Patients presenting for shoulder surgery will be randomized to receive desflurane or total intravenous anesthesia with propofol. Regional cerebral oxygenation will be measured using the INVOS 5100C monitor (Covidien, Boulder, CO). Depth of anesthesia will be maintained within a Bispectral Index range of 40-60. Following positioning, inspired oxygen fraction and minute ventilation will be sequentially adjusted. At each set point, regional cerebral oxygenation will be recorded and venous blood gas analysis performed. Statistical analysis will be repeated measures analysis of variance in which ventilation strategy is the within-subjects factor and anesthetic technique is the between-subjects factor; post hoc Tukey's correction will be used for multiple comparisons. If simple maneuvers of ventilation and anesthetic technique can prevent low brain oxygen levels, patient outcome may be improved.
Old
This is a prospective cohort study with randomized nested design. Patients presenting for shoulder surgery will be randomized to receive sevoflurane, desflurane or total intravenous anesthesia with propofol. Regional cerebral oxygenation will be measured using the INVOS 5100C monitor (Covidien, Boulder, CO). Depth of anesthesia will be maintained within a Bispectral Index range of 40-60. Following positioning, inspired oxygen fraction and minute ventilation will be sequentially adjusted. At each set point, regional cerebral oxygenation will be recorded and venous blood gas analysis performed. Statistical analysis will be repeated measures analysis of variance in which ventilation strategy is the within-subjects factor and anesthetic technique is the between-subjects factor; post hoc Bonferroni correction will be used for multiple comparisons. If simple maneuvers of ventilation and anesthetic technique can prevent low brain oxygen levels, patient outcome may be improved.
The eligibility criteria were updated.
New
Inclusion Criteria: - scheduled for elective arthroscopic shoulder surgery in the beach chair position under general anesthesia with supplemental interscalene block Exclusion Criteria: - refusal to give consent - ineligible for interscalene block - history of cardiovascular disease - history of cerebrovascular disease - hypertension - respiratory failure - non-English speaker
Old
Inclusion Criteria: - scheduled for elective shoulder surgery in the beach chair position under general anesthesia with supplemental interscalene block Exclusion Criteria: - refusal to give consent - ineligible for interscalene block - history of cardiovascular disease - history of cerebrovascular disease - hypertension - respiratory failure - non-English speaker