Using Transcranial Direct Current Stimulation (tDCS) to Improve Post-Stroke Aphasia

Completed

Phase 2 Results N/A

Trial Description

This study tests whether weak electrical stimulation of the brain is effective in improving language or reading difficulties occurring after a brain injury or stroke.

Detailed Description

This study tests whether aphasia or alexia, language and reading disorders occurring after traumatic brain injury or stroke, can be improved using transcranial direct current stimulation (tDCS). tDCS is a non-invasive technique that applies a small amount of direct electrical current to the brain in order to temporarily alter brain processing. Adults with aphasia/alexia resulting from stroke or traumatic brain injury will undergo baseline behavioral testing of various language and cognitive functions. Subjects who are willing to undergo MRI evaluation will also be scanned. They will then receive five days of either real or sham tDCS with standardized speech-language therapy, under a double-blind randomized placebo-controlled design. Behavioral assessments, and MRIs for those participating in the MRI portion of the study, will be performed again at multiple time points after completing tDCS to assess for changes in these measures.

Conditions

Interventions

  • Transcranial direct current stimulation Device
    Intervention Desc: The tDCS treatments will be applied bilaterally, with the anodal electrode placed on the left temple and the cathodal electrode placed on the right temple. The tDCS will be applied at the beginning of 60-minute speech-language treatment sessions for five days across a one-week period.
    ARM 1: Kind: Experimental
    Label: Transcranial Direct Current Stimulation
  • Sham stimulation Device
    Intervention Desc: The sham tDCS will be applied at the beginning of 60-minute speech-language treatment sessions for five days across a one-week period.
    ARM 1: Kind: Experimental
    Label: Sham Stimulation

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
  • Purpose: Treatment
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Western Aphasia Battery - Revised: Naming and Word Finding score Change from baseline to one day after treatment No
Secondary Western Aphasia Battery - Revised: Spontaneous Speech, Repetition, Auditory Verbal Comprehension and overall Aphasia Quotient Immediately; 2 weeks post-treatment; 12 weeks post-treatment No
Secondary Philadelphia Naming Test (PNT) Immediately; 2 weeks post-treatment; 12 weeks post-treatment No
Secondary Boston Diagnostic Aphasia Examination (BDAE): Verbal agility subtest Immediately; 2 weeks post-treatment; 12 weeks post-treatment No
Secondary Subjective assessments including: Communicative Effectiveness Index, Stroke and Aphasia Quality of Life Scale, and Stroke Aphasic Depression Questionnaire Immediately; 2 weeks post-treatment; 12 weeks post-treatment No
Secondary Cognitive-Linguistic Quick Test (CLQT) Immediately; 2 weeks post-treatment; 12 weeks post-treatment No
Secondary Reading assessments Immediately; 2 weeks post-treatment; 12 weeks post-treatment No
Secondary Motricity Index Immediately; 2 weeks post-treatment; 12 weeks post-treatment No

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