Using Repetitive Transcranial Magnetic Stimulation (rTMS) in the Rehabilitation of Chronic Spatial Neglect After Stroke "NEGLECT"


Phase 3 Results N/A

Eligibility Criteria

Inclusion Criteria

1. Unilateral right hemisphere stroke
2. Visuospatial neglect or extinction at the time of entry, as determined by at least 1 test of the battery (BEN) displaying pathological scores (cut off values as defined in AZOUVI et al. JNNP 2004, Table 1), or an ECB test, score > 8
3. A period of evolution of at least 3 months since stroke event
4. Age between 18 and 75 years old
5. Affiliation to Social Security system
6. Informed consent signature

Exclusion Criteria

1. Criteria related to the stroke:
- Bilateral stroke lesions: left hemispheric focal lesion excluding leucoaraiosis or mild lesions of the white matter
2. Criteria related to rTMS:
- Metal in the head, or a history of prior neurosurgical procedures
- Ferromagnetic bioimplants activated by any electronic, mechanical or magnetic means such as: cochlear implants, pacemakers, medication pumps, vagal stimulators, deep brain stimulators, neurostimulators, bio stimulators, or ventriculoperitoneal shunts.
- Prior history of seizures or seizure events following the stroke requiring the use of antiepileptic drugs
- Pregnancy (by history or positive urine pregnancy test)
- A urine pregnancy test will be done on all women of childbearing potential (those who have started menstruating up until they have stopped menstruating) prior to each MRI session, to rule out pregnancy.
- Diagnosis of tinnitus
- Participation in any experimental neglect rehabilitation project for at least 5 weeks before and 2 weeks after the stimulation, or during the 6 months of follow-up.
- Prior participation in TMS based treatments or experiments
3. Criteria related to feasibility:
- Incapacity to follow and complete the stimulation and follow-up protocol
- Other medical cerebral conditions other than the condition studied in the present protocol
- Any general medical condition, which could potentially interfere with clinical progression
- Any incapacitating psychiatric conditions, including significant history of substance abuse and severe depression
- Chronic treatment with medications that might modify cortical excitability
- Subjects with visual impediments that would limit our ability to obtain reliable testing