Using AtorVASTatin to Prevent VAscular Inflammatory OccLUSion in the Critically Ill "VASTVALUS"

Completed

Phase 2/3 Results N/A

Eligibility Criteria

Inclusion Criteria

- 1. Men or women >18 years of age
- 2. Admitted to a critical care unit and requiring at least a 48 hour critical care unit stay for medical reasons. Medical reasons include:
- conditions of cardiovascular,
- respiratory, or
- neurologic impairment that require supportive care and observation.

Exclusion Criteria

- 1. Hepatic failure (Childs-Pugh class C)
- 2. Rhabdomyolysis
- 3. Allergy or hypersensitivity to this drug or any of its components
- 4. Previous intolerance
- 5. Enrolment in another interventional trial
- 6. Contraindication to gastric and/or small bowel drug administration
- 7. MI as major diagnosis at admission (statin indicated)
- 8. Coronary artery intervention within previous 3 days
- 9. Currently receiving a statin or indicated (MI, dyslipidemia)
- 10. Pregnancy
- 11. personal or family history of hereditary muscular disorders
- 12. previous history of muscle toxicity with another HMG-CoA reductase Inhibitor
- 13. concomitant use of a fibrate or niacin
- 14. hypothyroidism
- 15. alcohol abuse
- 16. excessive physical exercise
- 17. renal impairment
- 18. diabetes with hepatic fatty change
- 19. surgery and trauma
- 20. frailty
- 21. situations where an increased plasma level of active ingredient may occur