The purpose of this study is to determine whether noninvasive brain stimulation associated with motor learning offers an additional benefit than motor learning alone in patients with stroke.
The investigators hypothesis is that active transcranial direct current stimulation (tDCS) combined with constraint induced movement therapy (CIMT) will induce a greater motor function improvement as compared with sham tDCS combined with CIMT.
More study details will be provided by Spaulding Rehabilitation Hospital.
- Transcranial Stimulation Device
Intervention Desc: Subjects will be stimulated at 1 mA for 40 minutes. ARM 1: Kind: Experimental Label: tDCS + CIMT Description: Participants will receive tDCS over the primary motor cortex (M1). We will use the following stimulation parameters: intensity of 1mA and for the first 40 minutes of constraint induced movement therapy (CIMT- 10 consecutive sessions Monday- Friday). ARM 2: Kind: Experimental Label: tDCS + motor training- Healthy Subjects Description: The investigators will have 40 healthy subjects who will undergo one day of treatment (in which the order in which they receive either sham or active tDCS stimulation will be randomized. Each stimulation day will include up to six hours of training termed "shaping" in the non-dominant hand while the dominant hand is restrained in a resting hand splint and secured in a sling. At the start of this training, subjects will undergo 40 minutes of either real tDCS at 1mA or sham tDCS. ARM 3: Kind: Experimental Label: tACS - Healthy Subjects Description: The investigators will have 40 healthy subjects who will undergo one day of treatment (in which the order in which they receive either sham or active transcranial alternating current stimulation (tACS) stimulation will be randomized.
- Allocation: Randomized
- Masking: Double Blind (Subject, Outcomes Assessor)
- Purpose: Treatment
- Endpoint: Efficacy Study
- Intervention: Parallel Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||Motor function||2 weeks||No|
|Secondary||Cortical excitability||2 weeks||No|