Use of Transcranial Direct Current Stimulation (tDCS) Coupled With Constraint Induced Movement Therapy in Stroke Patient "tdcs"

Active, not recruiting

Phase 2 Results N/A

Trial Description

The purpose of this study is to determine whether noninvasive brain stimulation associated with motor learning offers an additional benefit than motor learning alone in patients with stroke.
The investigators hypothesis is that active transcranial direct current stimulation (tDCS) combined with constraint induced movement therapy (CIMT) will induce a greater motor function improvement as compared with sham tDCS combined with CIMT.

Detailed Description

More study details will be provided by Spaulding Rehabilitation Hospital.

Conditions

Interventions

  • Transcranial Stimulation Device
    Intervention Desc: Subjects will be stimulated at 1 mA for 40 minutes.
    ARM 1: Kind: Experimental
    Label: tDCS + CIMT
    Description: Participants will receive tDCS over the primary motor cortex (M1). We will use the following stimulation parameters: intensity of 1mA and for the first 40 minutes of constraint induced movement therapy (CIMT- 10 consecutive sessions Monday- Friday).
    ARM 2: Kind: Experimental
    Label: tDCS + motor training- Healthy Subjects
    Description: The investigators will have 40 healthy subjects who will undergo one day of treatment (in which the order in which they receive either sham or active tDCS stimulation will be randomized. Each stimulation day will include up to six hours of training termed "shaping" in the non-dominant hand while the dominant hand is restrained in a resting hand splint and secured in a sling. At the start of this training, subjects will undergo 40 minutes of either real tDCS at 1mA or sham tDCS.
    ARM 3: Kind: Experimental
    Label: tACS - Healthy Subjects
    Description: The investigators will have 40 healthy subjects who will undergo one day of treatment (in which the order in which they receive either sham or active transcranial alternating current stimulation (tACS) stimulation will be randomized.

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Motor function 2 weeks No
Secondary Cortical excitability 2 weeks No

Sponsors