Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage


Phase N/A Results

Eligibility Criteria

Inclusion Criteria

- 18-85 years old inclusive
- Subarachnoid hemorrhage diagnosed by CT on admission
- Randomizable within 732 hours of subarachnoid hemorrhage
- Saccular intracranial aneurysm proven by cerebral angiography or computed tomographic angiography (CTA)
- Surgical or endovascular obliteration
- Able to obtain written informed consent from patient or surrogate

Exclusion Criteria

- Pregnancy, as confirmed by routine urine test on admission
- Elevated liver function test at time of randomization, defined as more than three times the upper limit of normal
- On Statins, niacin, or fibrate therapy within 30 days of presentation
- Any vasospasm on the initial diagnostic angiogram
- Glasgow Coma Scale 5 or less at the time of randomization
- History of liver disease or active liver disease
- Hypersensitivity to statins
- Patient taking medication not recommended for concomitant use with Simvastatin (40 or 80 mg) as per the product label