Use of Minocicline in Patients With Stroke

Recruiting

Phase 1 Results N/A

Trial Description

The investigators will evaluate the National Institute of Health Stroke Scale/Score (NIHSS)in patients with stroke, and then give Minocycline 100mg po every 12 hours or placebo for five days, then perform periodic evaluations to determine the status and degree of neurological sequelae developed.

Conditions

Interventions

  • Placebo Drug
    Intervention Desc: Pills with vegetable fibers one pill oral twice a day for five days
    ARM 1: Kind: Experimental
    Label: Placebo
    Description: Pills filled with vegetal fiber with similar presentation of the drug. Given one pill oral twice a day for five days
  • Minocicline Drug
    Intervention Desc: Minocicline 100mg oral twice a day for 5 days
    ARM 1: Kind: Experimental
    Label: Minocicline
    Description: minocicline 100mg oral twice a day for 5 days

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Investigator)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary To determine the efficacy of minocycline in reducing neurological sequelae in patients with stroke one year No
Secondary Identify the side effects of the intervention administered during the treatment time and 30 days later. one year Yes

Sponsors