US and Canadian Lubeluzole Ischemic Stroke Study "Lub"


Phase 3 Results

Eligibility Criteria

Inclusion Criteria

Clinical symptoms of acute ischemic stroke presenting within 6 hours of onset, alert or arousable to minor stimulation, exhibit a significant motor deficit of the arm or leg, and a total National Institutes of Health Stroke Scale (NIHSS) score of >7 at baseline. Must be at least 18 years of age.

Exclusion Criteria

Baseline CT scan inconsistent with the diagnosis of acute cerebral infarction, experience of a previous stroke with residual functional impairment; patients with a life-threatening concurrent illness, overt heart failure, myocardial infarction within the previous 6 weeks, electrocardiographic (ECG) findings of serious ventricular arrhythmia, second or third degree atrioventricular block, or a QT interval >450 msec were also excluded.