TRUST-tPA: Therapeutic Trial Evaluating Efficacy of Telemedicine (TELESTROKE) of Patients With Acute Stroke

Completed

Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria

- patients older than 18 years
- symptoms of brain infarction since less than 150 minutes
- NIHSS between 4 and 22
- No brain hemorrhage on contrast CT-scan
- Signed consent form by the patient or his relatives

Exclusion Criteria

- NIHSS above 22 or coma
- current oral anticoagulant or INR > 1.7
- heparin treatment within the preceding 24 hours or prolonged APTT (>40seconds)
- platelets count < 100 000/mm3
- another stroke or brain trauma within 3 months prior admission
- systolic blood pressure > 185 or diastolic blood pressure > 110 at the time od tPA treatment onset
- neurologic deficit is improving
- history of intracranial hemorrhage
- glycemia less than 0.5g/l or upper than 4g/l after treatment by Actrapid
- epileptic seizure at the time of stroke onset
- Gastro-intestinal or urinary hemorrhage
- Recent myocardial infarction within the last 21 days
- Lumbar puncture or arterial blood sampling in a non compressible vessel within the last 7 days
- Hemophilia
- Pregnancy or breast feeding
- Pericarditis within the last 3 months
- Major surgery within the last 15 days
- History of aortic dissection
- Endocarditis with the last 3 months
Brain CT scan exclusion criteria:
- Mass effect ( tumor, VAM, aneurism )
- Decreased density ( ASPECTS score < 8) or mass effect involving more than 1/3 of the territory of the middle cerebral artery