Treatment of Acute Stroke With Cromolyn(Single Dose)

Not yet recruiting

Phase 3 Results N/A

Trial Description

Mastocytes were proven to have a central rule in their development of the lipoid plaque of the vascular system. Mastocytes also has an important role in the stabilisation of the plaque in the building of the brain barrier. Different animal studies show that the inhibition of the mastocyte activity decreases significantly the risk of secondary bleeding post ischaemic stroke.It was also shown that post stroke inflammation process was also blocked by the inhibition of mastocytes.Other studies showed up to 100% decrease in the brain barrier disruption and post stroke oedema, after treatment with mastocyte inhibitors.
Cromolyn is a synthetic drug which has an anti-allergic effect by inhibition of the mastocytes. This drug is a well known,safe drug and is the main sub-substance that was used in the previously mentioned studies.

Conditions

Interventions

  • Sugar pill Drug
    Other Names: Placebo
    Intervention Desc: sugar pill Dissolved in water taken 4 times daily 30 minutes prior to meals
    ARM 1: Kind: Experimental
    Label: sugar pill
    Description: sugar pill dissolved in water to be given 4 times a day 30 minutes prior to meals
  • CROMOLYN Drug
    Other Names: Cromolyn sodium
    Intervention Desc: Cromolyn 200mg (dissolved in water) given 4 times a day
    ARM 1: Kind: Experimental
    Label: Cromolyn
    Description: Cromolyn dose of 200mg(dissolved in water) will be given 4 times a day(30 minutes before a meal)

Trial Design

  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
No outcomes associated with this trial.

Sponsors