Treadmill Exercise in Chronic Stroke Rehabilitation


Phase N/A Results

Trial Description

To determine whether treadmill aerobic training (T-AEX) is more effective than conventional rehabilitation to improve ambulatory function and cardiovascular fitness in patients with chronic stroke.


Trial Design

Randomized, controlled, single-blinded clinical trial.

Patient Involvement

Patients were randomized to 6 months (3x/week) progressive treadmill aerobic training (T-AEX) or a reference rehabilitation program of stretching plus low-intensity walking (R-CONTROL). Peak exercise capacity (VO2 peak), O2 consumption during submaximal effort walking (economy of gait), timed walks, Walking Impairment Questionnaire (WIQ), and Rivermead Mobility Index (RMI) were measured before and after 3 and 6 months of training.


Type Measure Time Frame Safety Issue
Primary Exercise testing was performed to measure economy of gait and VO2 peak at baseline and after 3 and 6 months training. Economy of gait was calculated to estimate metabolic demands of hemiparetic ambulation.
Secondary Measures of VO2 peak were used to index cardiovascular fitness.


The Baltimore Veterans Administration Geriatrics Research, Education, and Clinical Center.