This is a pilot study of repetitive transcranial magnetic stimulation (rTMS) to test tolerance and efficacy in children who have hemiparesis from acquired or presumed perinatal stroke.
The investigators will begin to test the hypothesis that rTMS will be tolerated and will result in improved hand strength and mobility when compared with sham stimulation.
Aim 1: To determine whether 1 Hz rTMS applied to the hemisphere opposite the infarct (contralesional or healthy hemisphere) is tolerated by children ages 6-18 years who have chronic motor sequelae from a stroke.
Aim 2: To determine whether 8 sessions of inhibitory 1 Hz rTMS to the contralesional healthy hemisphere improves grip strength and hand mobility when compared with sham stimulation in controls.
- Transcranial Magnetic Stimulation Device
Other Names: TMS Intervention Desc: Transcranial Magnetic Stimulation, repetitive at 1Hz ARM 1: Kind: Experimental Label: Magnetic Stimulation Description: Active Magnetic Stimulation
- Sham Magnetic Stimulation Device
Other Names: MagStim Intervention Desc: Sham Magnetic Stimulation ARM 1: Kind: Experimental Label: No Intervention Description: Sham Magnetic Stimulation
- Allocation: Randomized
- Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
- Purpose: Treatment
- Endpoint: Safety/Efficacy Study
- Intervention: Parallel Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||Tolerance to repetitive stimulation||Up to 2 days||Yes|
|Secondary||Upper extremity strength and mobility||Up to 2 Months||No|