Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea "TWiTCH"


Phase 3 Results N/A

Summary of Purpose

The primary goal of the Phase III TWiTCH trial is to compare 24 months of alternative therapy (hydroxyurea) to standard therapy (transfusions) for pediatric subjects with sickle cell anemia and abnormally high (≥200 cm/sec) Transcranial Doppler (TCD) velocities, who currently receive chronic transfusions to reduce the... Trial Stopped: The study was stopped early due to successfully meeting the primary endpoint

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 4 November 2015.

1 Aug 2011 19 Aug 2011 1 Mar 2015 1 Jan 2016 1 Nov 2015 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Design

  • Allocation: Randomized
  • Masking: Open Label
  • Purpose: Prevention
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment