Transcranial Direct Current Stimulation (tDCS) in Chronic Post-Stroke Apathy "TDCS-PSA"


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- Clinical diagnosis of stroke and radiographically proven ischemic or hemorrhagic stroke (MRI required for ischemic stroke, CT sufficient for hemorrhagic stroke)
- Stroke occurred at least one month prior to first stimulation session
- Ability to provide informed consent
- Availability of a family member / caregiver who knew the subject before the stroke and interacts with the subject on at least a weekly basis
- Score of 6 or higher in initial apathy testing using Apathy Inventory - Clinician score
- Speak English (required for quantifying apathy and performing the cognitive tests)

Exclusion Criteria

- Other potential cause of apathy including some neurodegenerative diseases, some psychiatric diseases, and anti-dopamine medication
- Prior brain injury (e.g., Traumatic Brain Injury (TBI), stroke) without full motor and cognitive recovery based on patient, family or clinician report
- Active medical illness (e.g., infection, delirium, etc.) that might affect arousal and cognitive function
- Hypoarousal (inability to maintain eye opening without stimulation) from any cause (e.g., stroke, sleep deprivation)
- Any history of epilepsy
- Recent drug or alcohol abuse - within the past year
- Pregnant or breastfeeding
- Moderate to severe aphasia preventing subject from communicating fully
- Any pacemakers, intracranial electrodes, implanted defibrillators, or any other electrical implants