Transcranial Direct Current Stimulation (tDCS)-Enhanced Stroke Recovery


Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- ischemic stroke causing arm weakness within 5-15 days
- no other neurological or psychiatric disease, who are able to perform study tasks

Exclusion Criteria

- patients younger than 18 or older than 80 years
- patients with more than one disabling stroke
- Patients with bilateral motor impairment
- Patients with poor motivational capacity, history of severe alcohol or drug abuse
- Patients with severe language disturbances, particularly of receptive nature
- Patients with serious cognitive deficits (defined as equivalent to a MMS score of 23 or less)
- Patients with severe uncontrolled medical problems (e.g., seizures, progressive stroke syndromes, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, end-stage pulmonary or cardiovascular disease, or a deteriorated condition due to age or others),
- Patients with unstable thyroid disease
- Patients with increased intracranial pressure
- Patients with unstable cardiac arrhythmia
- Patients with contraindication to TMS or tDCS stimulation (pacemaker, an implanted medication pump, a metal plate in the skull, or metal objects inside the eye or skull, patients who had a craniotomy, skin lesions at the site of stimulation)
- Patients who are not available for follow-up at 3 and 12 months
- Pregnancy
- Patients with contraindication to MRI will not participate in MRI