Transcranial Direct Current Stimulation and Aphasia Language Therapy


Phase 1 Results N/A

Eligibility Criteria

Inclusion Criteria

- A single unilateral left-hemisphere infarct that is confirmed by CT scan or MRI
- Nonfluent aphasia, with a mean length of utterance of 0-4 words and an Aphasia Quotient score on the Western Aphasia Battery of 25-70
- Age 21 or older
- At least 6 months post-stroke
- Premorbidly right-handed, as determined by the Edinburgh Handedness Inventory
- Premorbidly literate in English
- Completed at least an eighth grade education
- Visual acuity no worse than 20/100 corrected in the better eye
- Auditory acuity, aided in the better ear, no worse than 30 dB HL on a pure tone hearing screening (conducted at 500, 1000, 2000, and 4000 Hz.)

Exclusion Criteria

- Any other neurological condition (other than cerebral vascular disease) that could potentially affect cognition or speech, such as Parkinson's Disease, Alzheimer's Dementia, traumatic brain injury
- Any significant psychiatric history prior to the stroke, such as severe major depression or psychotic disorder requiring hospitalization; subjects with mood disorders who are currently stable on treatment will be considered
- Active substance abuse
- Seizure disorder that precludes safe participation in this trial
- Absence of left hemisphere activation during two of the three fMRI tasks
- Presence of lesions that encompass premotor cortex from the Sylvian fissure to a point high on the convexity