Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion "TANDEM-1"


Phase 2 Results N/A

Summary of Purpose

Iron overload has been associated with greater brain injury in ischemia/reperfusion experimental stroke models and ischemic stroke patients, especially in those treated with thrombolytic treatment. Deferoxamine administration, an iron chelator, offers a neuroprotective action in ischemia/reperfusion animal models. Primary objective: To evaluate the security and tolerability of deferoxamine endovenous ...

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 4 July 2012.

1 Sep 2008 21 Oct 2008 1 Dec 2011 1 Dec 2011 1 Jul 2012 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment


  • Natalia Pérez de la Ossa, MD 0034 93 4978911

  • Monica Millán Torné, MD