Inclusion Criteria1. Patients with a clinical indication for carotid revascularization (CRV) as decided by the treating physicians (the clinical indications for CRV as well as the choice of the type of CRV, either CEA or CAS, will be entirely up to the treating physicians)
2. Patients who can perform the neurocognitive tests in English
3. Women of childbearing age who are non-lactating and have a negative pregnancy test
4. Patients in the age range of 18 years - 90 years
5. Patients able to undergo MRI imaging.
6. Patients that are dependable and able to return for follow-up studies and exams.
7. Patients that will be in the hospital (inpatients) the day prior to the procedure for clinical purposes (for evaluation of side effects from the first dose and for overnight infusion of minocycline before the procedure)
Exclusion Criteria1. Known hypersensitivity to tetracyclines
2. Significant neurological deficit including but not limited to dense aphasia, hemi- or mono-paresis (motor strength equal or less than 3/5) or neglect.
3. Baseline abnormalities on the MRI of the brain which would preclude the detection of new DWI or FLAIR changes. (e.g large areas of acute stroke, large areas of previous encephalomalacia, existing hardware such as aneurysm clips or coil masses etc.)
4. Patients who are pregnant, breast-feeding, or lactating.
5. Patients with a contraindication to undergo MRI, including those with pacemakers, metal implants and metal fragments within their bodies.
6. Patients with abnormal liver function tests at baseline defined as a 2-fold elevation in alanine-aminotransferase.
7. Patients with significantly affected renal function at baseline (Creatinine equal or above 2mg/dL).
8. Patients on high dose isotretinoin, vitamin A, or methotrexate
9. Patients undergoing emergency carotid revascularization procedures.
10. Any clinically important known medical, surgical, psychiatric or psychological disease, which would preclude completion of the protocol (such as advanced cardiac, renal or pulmonary disease).We will screen for physical and mental capacity to undergo study procedures and will obtain proxy consent for subjects who appear decisionally impaired. The screening process will be performed by the physician co-investigator obtaining the informed consent.
11. Patients with a Mini-Mental Status Exam score (MMSE) of less than 21 (as determined by one of the co-investigators). Patients with MMSE score of 21 will be included.
12. Patients undergoing carotid revascularization in less than 36 hours from identification, or patients who are undecided about participation less than 36 hours prior to the procedure will not be eligible for the study.
13. Patients with any other factor that would make follow-up studies difficult (e.g patient is from another country, or patient is a prisoner)