The Relationship Between Motor Cortex Oxygenation and Motor Function Recovery in Stroke Patients

Enrolling by invitation

Phase N/A Results N/A

Trial Description

Stroke is the most common cause of motor function impairment. However, the functional impairment is not totally irreversible. Several mechanisms may involved in both the cortical and motor function recovery after onset of stroke, and most of them are related to changes of cortical perfusion and metabolism.
Motor function recovery after stroke (especially middle cerebral artery territory lesion) frequently follow stereotypic pattern (brunnström stage).
This study is designed to investigate the relationship between motor cortex oxygenation/metabolism and motor function recovery after stroke. To seek if there is similar stereotypic pattern of motor cortex oxygenation/metabolism change during the recover stage after stroke.

Detailed Description

Participants receive evaluations (1/week for 3 months period) of
- motor function (Include: MMSE, brunnström stage, Fugl-Meyer Assessment of Physical Performance, Box and Block Test of Manual Dexterity, Functional Independence Measure)
- cortical perfusion detection during performing limb movements (using NIRS)
Then use path analysis to investigate the relationship between motor cortex oxygenation/metabolism and motor function recovery after stroke.

Conditions

Interventions

  • Functional Electric Stimulation Procedure
    Intervention Desc: apply to the hemiplegia affected limbs, helping movement
    ARM 1: Kind: Experimental
    Label: Functional Electric Stimulation
    Description: perform arm cranking with functional electrical stimulation
  • Rehabilitation programs Other
    Intervention Desc: include occupational therapy and physical therapy
    ARM 1: Kind: Experimental
    Label: traditional rehabilitation program
    Description: traditional rehabilitation program

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Outcomes Assessor)
  • Purpose: Basic Science
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Cortical activation weekly changes within 3 months No
Secondary motor function weekly changes within 3 months No

Sponsors