Eligibility Criteria

Inclusion Criteria

- Adults older than 20 years
- Patients with acute stroke (ischemic stroke or cerebral hemorrhage) confirmed by neuroimaging within 21 days after stroke onset
- Patients with hemorrhagic transformation of infarcted tissue will not be included, but if investigators judge the risk of bleeding is small (i.e., reduced amount of blood in follow-up neuroimaging) those patients can be enrolled.
- Patients with MRS ≥ 2 on screening
- Patients without definite history of depression
- Patients who fulfill the following criteria in the K-MADRS test:
The combined score of the 9th question (pessimistic thoughts) and the 10th question (suicidal idea) ≤ 7 The score of the 10th question < 6
- Patients without serious communication problem
- Patients who agree to participate in this trial

Exclusion Criteria

- Patients with MRS 0 or 1 on screening
- Patients who have definite history of depression or have taken antidepressants
- Patients who have been diagnosed as having bipolar disorder or other psychiatric disorders
- Patients with severe dementia or aphasia. However, those who have motor aphasia but are still communicable can be enrolled
- Patients who have taken migraine medication on screening or those who are expected to take migraine medication frequently due to severe migraine
- Patients who have strong suicidal idea on screening test or those who express their wish to be treated for depression
- Patients who are considered to be treated for depression by charged physicians
- Patients who need SSRI medication for other reasons
- Patients who have taken antiepileptic drugs on screening
- Patients who have a history of traumatic brain injury, brain tumor, or other brain disease (except stroke) within 30 days prior to screening
- Patients with uncommon causes of stroke (e.g. subarachnoid hemorrhage, venous thrombosis, arteriovenous malformation, or Moyamoya disease)
- Patients with bleeding diathesis, hemophilia, or thrombocytopenia
- Patients with severe concomitant illness (e.g. liver disease, renal disease, malignancy)
- Patients with abnormal blood tests Abnormal LFT (ALT > 200 or AST > 200) Anemia (Hb < 8 mg/dl) or thrombocytopenia (<100,000/mm3) Renal insufficiency (Cr > 3.0 mg/dl) or renal failure requiring dialysis Patients with severe heart failure (NYHA class III or IV) NYHA classification for heart failure Class I : patients with no limitation of activities; they suffer no symptoms from Ordinary activities Class II : patients with slight, mild limitation of activity; they are comfortable with rest or with mild exertion Class III : patients with marked limitation of activity; they are comfortable only at rest Class IV : patients who should be at complete rest, confined to bed or chair; any activity brings on
- Pregnant or lactating patients
- Patients who are participating in another clinical trial, but those who are participating in the observational study can be enrolled