The PERFusion Use in Stroke Evaluation Study "PERFUSE"

Recruiting

Phase N/A Results N/A

Trial Description

This is an open label single center phase II trial, evaluating the utility of 64 slice CT perfusion (CTP) in acute ischemic stroke (AIS) patients. The main aim is to determine which aspects of CTP imaging can aid in expanding the time window for thrombolysis with IV (rt-PA) in AIS patients up to 6 hours after symptom onset.

Conditions

Interventions

  • Computed tomography perfusion imaging Other
    Intervention Desc: As per standard of care at CPMC
    ARM 1: Kind: Experimental
    Label: Acute ischemic stroke patients
    Description: All acute ischemic stroke patients receiving IV rt-PA within 6 hours of symptom onset

Trial Design

  • Observation: Cohort
  • Perspective: Prospective
  • Sampling: Non-Probability Sample

Trial Population

All acute ischemic stroke patients who present to the emergency room at CPMC who receive IV rt-PA within 6 hours of symptom onset

Outcomes

Type Measure Time Frame Safety Issue
Primary Final infarct volume 24 hour post-thrombolysis No
Secondary Large vessel occlusion on neuroimaging 24 hours post-thrombolysis No
Secondary NIHSS 24-hours from tPA adminsitration No
Secondary Symptomatic intracerebral hemorrhage post-thrombolysis 24 hours post-thrombolysis Yes
Secondary Modified Rankin Scale 3-months from tPA administration No

Sponsors