The Neuroprotective Effect of Remote Ischemic Preconditioning on Ischemic Cerebral Vascular Disease

Completed

Phase 1/2 Results

Update History

26 Apr '12
Trial was updated to "Phase 1/Phase 2."
The minimum age criteria for eligibility was updated to "18 Years."
The eligibility criteria were updated.
New
Inclusion criteria: 1. Patients with stroke or transient ischemic attack (TIA) within 180 days and the neurologic deficits were well matched to the territory of the stenosed artery, with intracranial arterial stenosis of at least 50% by angiography, at least 70% by ultrasound, or at least 70% by computed tomographic angiography (CTA) or magnetic resonance angiography (MRA) 2. Age between 18 to 80 years old 3. Trial of Org 10172 in Acute Stroke Treatment-1 (TOAST-1) subtype 4. National Institutes of Health Stroke Scale (NIHSS) score 0-15, and Modified Rankin Scale (mRS) score 0-4. 5. ABCD2 score between 6 to 7 6. Stable vital signs, normal hepatic and renal functions, 7. No hemorrhagic tendencies. Exclusion criteria: 1. Within 72 hrs of intra-artery or intravenous thrombolysis 2. Intracranial hemorrhage or large area of cerebral infarction (more than 1/3 middle cerebral artery perfusion territory) 3. Any soft tissue, orthopedic, or vascular injury, wounds or fractures in extremities which may pose a contraindication for application of the preconditioning cuffs 4. Acute myocardial infarction 5. Systolic blood pressure more than 200 mmHg after drug control 6. Peripheral blood vessel disease 7. Hematologic disease 8. Severe hepatic and renal dysfunction 9. Severe or unstable concomitant disease 10. Cannot tolerate BLIPC or without informed consent 11. Patients who did not complete the whole treatment procedure.
Old
Inclusion Criteria: - Patients with chronic ischemic cerebral vascular disease, including ischemic stroke and transient ischemic attack (TIA). 1. Symptomatic patients, as evidenced by TIA, amaurosis fugax, minor or non-disabling stroke. 2. Magnetic resonance angiography(MRA), ultrasound or digital subtraction angiography (DSA) defined the target cerebral vessel occlusion or stenosis. 3. Patients signed the informed consent. Exclusion Criteria: 1. Evolving stroke 2. Intolerance or allergic reaction to any of the study medications, including aspirin (ASA) and clopidogrel. 3. Severe dementia. 4. Hemorrhagic transformation of an ischemic stroke within the past 60 days. 5. Chronic atrial fibrillation. 6. MI within previous 30 days. 7. Bilateral upper limb arteries are severe stenosis or occlusion.
A location was updated in Xicheng District.
New
The overall status was removed for Xuanwu Hospital, Capital Medical University.