The Efficacy of Citalopram Treatment in Acute Stroke "TALOS"


Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- First ever ischemic stroke
- Age 18 years or above

Exclusion Criteria

- Hemorrhagic stroke
- Dementia or other neurodegenerative disease
- Antidepressant medical treatment within 6 months of admission
- Acute need for antidepressant treatment
- Drug abuse or other conditions that may indicate noncompliant behavior
- Liver failure (increased liver enzyme levels up to or more than 2 times upper limit)
- Renal failure (eGFR below 30 ml/min per 1.73m2)
- Hyponatremia (S-potassium below 130 mmol/l)
- Actively bleeding ulcer
- Fatal stroke or other severe co-morbidity that markedly decreases expected life span
- Prolonged corrected QT-interval (QTc above 480 ms)
- Ongoing treatment with drugs known to prolong the QTc interval