The Effect of Methylphenidate on Motor Learning in Stroke Patients


Phase 4 Results N/A

Trial Description

The purpose of the study is to determine whether methylphenidate facilitates so called short-term plasticity as measures with transcranial magnetic stimulation, in patients with stroke.

Detailed Description

Stroke patients are to be examined with transcranial magnetic stimulation (TMS) before and after a short training session. TMS will be used to demonstrate changes in cortical excitability (motor threshold) and intracortical inhibition and facilitation. The effect of methylphenidate on baseline TMS measures will be evaluated as well as the effect on training induced changes in TMS measures (by comparing baseline and posttraining measures). The patients will be trained on two separate occasions, to compare the effect of Methylphenidate to placebo.

Trial Stopped: Recruitment of patients proved much too difficult based on the chosen criteria.



Trial Design

  • Allocation: Randomized
  • Masking: Double-Blind
  • Purpose: Treatment
  • Endpoint: Pharmacodynamics Study
  • Intervention: Crossover Assignment


Type Measure Time Frame Safety Issue
Primary Training induced changes in Short interval Intracortical Inhibition (SICI).
Primary Training induced changes in Intracortical facilitation (ICF)
Secondary Baseline SICI, ICF, and motor threshold compared between methylphenidate and Placebo