The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED)


Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria

- Patient With Tia Or Ischemic Stroke (Event Has Occurred More Thaan 4 Weeks But Less Than 24 Weeks, And Modified Rankin'S Scale, Mrs<=3) With Mild To Moderate Hypertension
- Patient Has No Other Active Medical Problem, Which Might Of Itself Or By This Treatment Significantly Affect The Patient's Blood Pressure
- The Blood Level Of Hscrp>0.2 Ng/Dl By Two Measurements Performed Respectively One-Week Apart

Exclusion Criteria

- Patients With Cardiac Arrhythmia
- Diabetes Mellitus
- Patient With Other Active Inflammatory Diseases Such As Rheumatoid Disease, Fever And Systemic Infection Which Will Confound The Level Of Serum CRP
- Patients With Known Intolerance, Contraindication Or Hypersensitivity To Losartan, Amlodipine and Hydrochlorothiazide
- Patient With Myocardial Infarction Within The Recent Three Months
- Anatomy Abnormality Which Results In Poor Bilateral Temporal Acoustic Windows Which Prevent TCD Procedure
- Patient Who Requires Continuous Medication With Alpha Blocking Agents
- Concurrent Usage Of Acei
- Poor Mental Function Or Any Other Reason To Expect Difficulty In Meeting The Requirements Of The Study
- Concurrent Treatment With Other Lipid-Lowering Drug
- Childbearing Potential Women Not Undergoing Adequate Contraceptive Control