The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED)

Completed

Phase 4 Results N/A

Trial Description

To compare the effect of losartan vs amlodipine-based antihypertensive therapy on atherosclerotic inflammatory markers and cerebrovascular regulation in Ischemic stroke patients.

Conditions

Interventions

  • Amlodipine Drug
    Intervention Desc: amlodipine 5 mg q.d for 30 weeks.
    ARM 1: Kind: Experimental
    Label: B
    Description: Amlodipine 5 mg q.d for 30 weeks, if blood pressure > 140/90, or mean arterial Bp ? 15% of baseline, then add on diuretics.
  • Losartan (Cozaar)Drug
    Other Names: losartan potassium; COZAAR®; MK0954
    Intervention Desc: losartan 50mg qd for 30 weeks.
    ARM 1: Kind: Experimental
    Label: A
    Description: Losartan 50mg qd for 30 weeks, if blood pressure > 140/90, or mean arterial Bp ? 15% of baseline, then add on diuretics.

Trial Design

  • Allocation: Randomized
  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary MCAFV and TCD for measuring cerebral autoregulatory indices at week 0, week 6, week 18 and week 30. At week 0, week 6, week 18 and week 30. No

Sponsors