The Effect of Erigeron Injection on Acute Cerebral Infarction Serum VEGF, MMP-9 and EPC Levels

Not yet recruiting

Phase 4 Results N/A

Trial Description

To study the effects of Erigeron Injection on human serum VEGF, MMP-9 and EPC levels after acute cerebral infarction,test is made by random double-blind controlled.patients with acute cerebral infarction were divided randomly into erigeron injection+aspirin group,aspirin group,and health people. The main indexes are the serum level of VEGF, MMP-9 and EPC.The review is made by the reference to NIHSS and so on. So, Erigeron Injection have the function of promoting angiogenesis in multiple targets through this test.

Detailed Description

OBJECTIVE:
To study the effects of Erigeron Injection on human serum VEGF, MMP-9 and EPC levels after acute cerebral infarction.
METHOD:
40 patients with acute cerebral infarction(in accordance with the inclusion criteria) were divided randomly into erigeron injection+aspirin group,aspirin group,and 20 health people. Erigeron injection+aspirin group and aspirin group drew peripheral blood on the prior treatment,the posttreatment 1th, 3th and 7th day,and tested the level of VEGF, MMP-9 and EPC.Tested the health people one time.

Conditions

Interventions

  • Placebo Drug
    Intervention Desc: normal saline, 500ml,i.v.,qd, for 7 days
    ARM 1: Kind: Experimental
    Label: placebo
    Description: normal saline, 500ml,i.v.,qd, for 7 days
  • Erigeron Injection Drug
    Intervention Desc: Erigeron Injection, 30ml, iv, qd, for 7days
    ARM 1: Kind: Experimental
    Label: Erigeron Injection
    Description: Erigeron Injection, 30ml,qd,i.v., for 7 days

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary the serum level of VEGF,MMP-9 and EPC 0-7days No
Secondary National Institute of Health of stroke scale 0-7days No

Sponsors