The Darbepoetin Alfa for Ischemic Surgical Complications (DISC) Dose Finding Trial "DISC"


Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- Are men and women between the ages of 18 - 100 years old (inclusive)
- Require descending thoracic or thoracoabdominal aorta surgical repair
- Can provide informed consent

Exclusion Criteria

- Have a traumatic aortic dissection
- Have a baseline NIHSS > 1 or modified Rankin Scale > 1
- Have a history of stroke or myocardial infarction within the past 30 days
- Have a preoperative hemoglobin < 9 or > 14
- Have a history of polycythemia vera or essential thrombocytosis
- Have a history of hematologic malignancy
- Have a history of arterial or venous thrombosis in the past three months
- Have uncontrolled hypertension
- Have active malignancy requiring treatment
- Are receiving hemodialysis
- Are currently using recombinant human erythropoietin or darbepoetin alfa, or have an expectation to require these medications within 30 days of surgery.
- Have a known allergy to recombinant human erythropoietin or darbepoetin alfa
- Are pregnant or breast-feeding. Women of childbearing potential must have a negative pregnancy test (urine pregnancy test or serum beta-HCG)