Systolic Hypertension in the Elderly Program "SHEP"

Completed

Phase N/A Results

Trial Description

To investigate antihypertensive drug treatment effects on incidence of stroke in elderly patients with isolated systolic hypertension.

Interventions

  • Antihypertensives Drug
    Intervention Desc: This category includes all BP lowering drugs in stroke prevention trials

Trial Design

Randomized, stratified, double-blind, placebo-controlled trial of 4736 patients at 16 centers. Stratification was by clinical center and by antihypertensive medication status at initial contact.

Patient Involvement

Patients were randomly assigned to receive treatment with 12.5 mg/d of chlorthalidone or placebo; if the patient's SBP in the active treatment group was not controlled at goal, the dosage of chlorthalidone was doubled and either 25 mg/d of atenolol or 0.05 mg/d of reserpine could be added and the dosages of these drugs could also be doubled if necessary; Average follow-up period was 4.5 years.

Outcomes

Type Measure Time Frame Safety Issue
Primary Nonfatal and fatal (total) stroke.
Secondary Cardiovascular and coronary morbidity and mortality, all-cause mortality, and quality of life measures.

Sponsors

National Heart, Lung, and Blood Institute and the National Institute on Aging