To investigate antihypertensive drug treatment effects on incidence of stroke in elderly patients with isolated systolic hypertension.
- Antihypertensives Drug
Intervention Desc: This category includes all BP lowering drugs in stroke prevention trials
Randomized, stratified, double-blind, placebo-controlled trial of 4736 patients at 16 centers. Stratification was by clinical center and by antihypertensive medication status at initial contact.
Patients were randomly assigned to receive treatment with 12.5 mg/d of chlorthalidone or placebo; if the patient's SBP in the active treatment group was not controlled at goal, the dosage of chlorthalidone was doubled and either 25 mg/d of atenolol or 0.05 mg/d of reserpine could be added and the dosages of these drugs could also be doubled if necessary; Average follow-up period was 4.5 years.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Nonfatal and fatal (total) stroke.|
|Secondary||Cardiovascular and coronary morbidity and mortality, all-cause mortality, and quality of life measures.|