Synchronous rTMS and Computer-integrated Speech Training Applied in Aphasic Patients and the Neuroimaging Study

Recruiting

Phase N/A Results N/A

Trial Description

The refinement of repetitive transcranial magnetic stimulation (rTMS) has highlighted its merit in terms of learning programs as a treatment for aftereffect augmentation. Nevertheless, the efficacy of synchronous rTMS protocol integrated with computer-integrated speech training is not well understood. It is also not clear regarding the efficacy of compound bi-hemispheric stimulation protocol. The aim of the study is to investigate language response to these new strategies and to determine the longevity of the therapeutic outcome. Advanced MR neuroimaging techniques, such as fMRI and DTI, are powerful tools to evaluate the concomitant nervous changes after rTMS treatment on aphasic patients. The knowledge from fMRI and DTI microstructural evolution provides insight into underlined mechanism operating the language improvement.

Detailed Description

The efficacy of synchronous rTMS protocol integrated with computer-integrated speech training is not well understood. It is also not clear regarding the efficacy of compound bi-hemispheric stimulation protocol. The aim of the study is to investigate language response to these new strategies and to determine the longevity of the therapeutic outcome. Advanced MR neuroimaging techniques, such as fMRI and DTI, are powerful tools to evaluate the concomitant nervous changes after rTMS treatment on aphasic patients. The knowledge from fMRI and DTI microstructural evolution provides insight into underlined mechanism operating the language improvement

Conditions

Interventions

  • Repetitive Transcranial Magnetic Stimulation (rTMS) Device
    Intervention Desc: undergo 10-min of contralesional 1Hz repetitive transcranial magnetic stimulation(rTMS) or 10-min ipsilesional 5-Hz rTMS for 10 daily sessions
    ARM 1: Kind: Experimental
    Label: Experimental
    Description: repetitive transcranial magnetic stimulation (rTMS) intervention for 10-min of contralesional 1Hz-repetitive transcranial magnetic stimulation(rTMS) or 10-min ipsilesional 5-Hz rTMS for 10 daily sessions; Computer-integrated Speech Training for 20 mins
  • Sham stimulation Device
    Intervention Desc: 2-week inhibitory non-dominate hemisphere rTMS program
    ARM 1: Kind: Experimental
    Label: Sham stimulation
    Description: Sham treatment for 2-week inhibitory non-dominate hemisphere rTMS program. Computer-integrated Speech Training for 20 mins
  • Computer-integrated Speech Training Behavioral
    Intervention Desc: Computer-integrated Speech Training program for 20 mins
    ARM 1: Kind: Experimental
    Label: Experimental
    Description: repetitive transcranial magnetic stimulation (rTMS) intervention for 10-min of contralesional 1Hz-repetitive transcranial magnetic stimulation(rTMS) or 10-min ipsilesional 5-Hz rTMS for 10 daily sessions; Computer-integrated Speech Training for 20 mins
    ARM 2: Kind: Experimental
    Label: Sham stimulation
    Description: Sham treatment for 2-week inhibitory non-dominate hemisphere rTMS program. Computer-integrated Speech Training for 20 mins

Outcomes

Type Measure Time Frame Safety Issue
Primary Change From Baseline in aphasia level on the Concise Chinese Aphasia Test (CCAT) at 2 Weeks baseline and 2 weeks
Secondary Change from Baseline in the concomitant nervous status on the Functional magnetic resonance imaging (fMRI) at 2 weeks baseline and 2 weeks

Sponsors