Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy "SuSPect-CAA"

Active, not recruiting

Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria (study group):
- Fulfillment of the modified Boston criteria for CAA-related hemorrhage with evidence of supratentorial superficial siderosis on MRI
- MR-/CT-/digital subtraction (DS) -angiography without evidence of cerebral aneurysm, arterio-venous malformation (AVM) , AV-fistula or other pathology of relevance (e.g. tumor, hemorrhagic infarction)
- A maximum of two lobar or cerebellar intracranial hemorrhages (ICH) (old or acute)
- Written informed consent by patient or guardian prior to study participation
- Willingness to participate in follow-up
Inclusion Criteria (control group):
- Fulfillment of the classic Boston criteria for CAA-related hemorrhage
- Absence of superficial siderosis on MRI
- A maximum of two lobar or cerebellar ICHs (old or acute)
- MR-/CT-/DS -angiography without evidence of cerebral aneurysm, AVM, AV-fistula or other pathology of relevance (e.g. tumor, hemorrhagic infarction)
- Written informed consent by patient or guardian prior to study participation
- Willingness to participate in follow-up
Exclusion Criteria (both groups):
- Severe medical condition with expected life expectancy <3 years
- More than two lobar or cerebellar ICH (old or acute)
- any intracerebral hemorrhage in the deep grey matter (basal ganglia or thalami) or in the brain stem
- History of head trauma resulting in loss of consciousness or radiologically visible traumatic brain injury (contusions, diffuse axonal damage) in the last 5 years prior to inclusion
- Cerebral aneurysm or history of aneurysmal subarachnoid hemorrhage
- Infratentorial siderosis
- Infratentorial subarachnoid hemorrhage