Study to Evaluate Carotid Ultrasound changes in patients treated with Ramipril and vitamin E "SECURE"


Phase N/A Results

Eligibility Criteria

Inclusion Criteria

Patients who were older than 55, who had vascular disease or diabetes in addition to at least one other cardiovascular risk factor, and whose B-mode carotid ultrasounds (CUS) could accurately measure at least four predetermined carotid arterial segments.

Exclusion Criteria

Patients who had heart failure, left ventricular ejection fraction <0.40, a history of myocardial infarction, unstable angina or stroke within 1 month before study enrollment, who used an ACE inhibitor or vitamin E, who had blood pressures >160/90, overt nephropathy, or any major illness expected to affect trial participation, were excluded from the study.