Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine "SEARCH"

Completed

Phase 3 Results

Eligibility Criteria

Inclusion Criteria

- Prior myocardial infarction
- Statin therapy indicated
- No clear indication for folic acid

Exclusion Criteria

- No clear contraindication to study treatments
- Screening plasma total cholesterol <3.5 mmol/l in patient already on statin therapy, or <4.5 mmol/l in patient not on statin therapy
- Chronic liver disease
- Severe renal disease or evidence of renal impairment
- Inflammatory muscle disease
- Concurrent treatment with fibrates or high-dose niacin
- Concurrent treatment with cyclosporin (or condition likely to result in organ transplantation and the need for cyclosporin), nefazodone, methotrexate, systemic azole antifungal or systemic macrolide antibiotics
- Child bearing potential
- No other predominant medical problem (other than coronary heart disease [CHD]) which might limit compliance with 5 years of study treatment