Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine "SEARCH"


Phase 3 Results

Summary of Purpose

SEARCH is a randomised, double-blind, multi-centre United Kingdom (UK) trial of 12,064 patients with myocardial infarction (MI) prior to study entry which aims to demonstrate whether a more intensive cholesterol lowering regimen using 80 mg simvastatin daily produces a larger and worthwhile reduction in cardiovascular events compared with a standard 20 mg daily regimen and whether reducing blood homocysteine...

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 31 January 2012.

1 Jul 1998 22 Jul 2005 1 May 2008 1 May 2008 1 Jan 2012 29 Mar 2010
Start Date First Received 1st Completion Completion Verification Results

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
  • Purpose: Prevention
  • Endpoint: Safety/Efficacy Study
  • Intervention: Factorial Assignment


Not available