Study Evaluating The Safety And Efficacy Of PF-03049423 In Subjects With Ischemic Stroke

Terminated

Phase 2 Results

Update History

1 Feb '14
The description was updated.
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The interim analysis for the POC study A9541004 demonstrated futility, and the study was stopped on the 6th of November 2013. There were no signals of serious safety concern.
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None.
25 Jan '14
A location was updated in Birmingham.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Birmingham.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Deerfield Beach.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Fort Lauderdale.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Port Charlotte.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Fort Wayne.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Fort Wayne.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Boston.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Detroit.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in St. Louis.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Chapel Hill.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Chapel Hill.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Oklahoma City.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Hershey.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Hummelstown.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Houston.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Pleven.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Plovdiv.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Edmonton.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Brno.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Plzen - Lochotin.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Bordeaux.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Limoges.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Paris CEDEX 13.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Altenburg.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Berlin.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Essen.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Leipzig.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Muenchen.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Muenster.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Regensburg.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Balassagyarmat.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Gyor.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Hyderabad.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Pune.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in New Delhi.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seongnam-si.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Anyang-si.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Gwangju.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Incheon.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Kaohsiung.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Taichung.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Taipei.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Taoyuan County.
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The overall status was removed for Pfizer Investigational Site.
18 Dec '13
A location was updated in Birmingham.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Birmingham.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Deerfield Beach.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Fort Lauderdale.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Port Charlotte.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Fort Wayne.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Fort Wayne.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Boston.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Detroit.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Golden Valley.
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The overall status was updated to "Not yet recruiting" at Pfizer Investigational Site.
A location was updated in Robbinsdale.
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The overall status was updated to "Not yet recruiting" at Pfizer Investigational Site.
A location was updated in St. Louis.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Chapel Hill.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Chapel Hill.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Oklahoma City.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Hershey.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Hummelstown.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Houston.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Pleven.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Plovdiv.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Edmonton.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Brno.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Jihlava.
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The overall status was updated to "Not yet recruiting" at Pfizer Investigational Site.
A location was updated in Plzen - Lochotin.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Bordeaux.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Limoges.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Paris CEDEX 13.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Altenburg.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Berlin.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Essen.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Leipzig.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Muenchen.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Muenster.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Regensburg.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Balassagyarmat.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Gyor.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Hyderabad.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Pune.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in New Delhi.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seongnam-si.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Anyang-si.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
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The overall status was updated to "Terminated" at Pfizer Investigational Site.
A location was updated in Gwangju.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Incheon.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Kaohsiung.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Taichung.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Taipei.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Taoyuan County.
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The overall status was removed for Pfizer Investigational Site.
20 Nov '13
A location was updated in Birmingham.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Birmingham.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Deerfield Beach.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Fort Lauderdale.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Port Charlotte.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Fort Wayne.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Boston.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Detroit.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Golden Valley.
New
The overall status was updated to "Not yet recruiting" at Pfizer Investigational Site.
A location was updated in Robbinsdale.
New
The overall status was updated to "Not yet recruiting" at Pfizer Investigational Site.
A location was updated in St. Louis.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Chapel Hill.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Chapel Hill.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Oklahoma City.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Hershey.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Hummelstown.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Pawtucket.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Providence.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Houston.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Pleven.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Plovdiv.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Edmonton.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Brno.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Jihlava.
New
The overall status was updated to "Not yet recruiting" at Pfizer Investigational Site.
A location was updated in Plzen - Lochotin.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Bordeaux.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Limoges.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Paris CEDEX 13.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Altenburg.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Berlin.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Essen.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Leipzig.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Muenchen.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Muenster.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Regensburg.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Balassagyarmat.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Gyor.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Hyderabad.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Pune.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in New Delhi.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Seongnam-si.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Anyang-si.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
New
The overall status was updated to "Terminated" at Pfizer Investigational Site.
A location was updated in Gwangju.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Incheon.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Monterrey.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Kaohsiung.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Taichung.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Taipei.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Taoyuan County.
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The overall status was removed for Pfizer Investigational Site.
17 Oct '13
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
14 Aug '13
A location was updated in St. Louis.
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The overall status was removed for Pfizer Investigational Site.
17 Jul '13
A location was updated in Chapel Hill.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Chapel Hill.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Budapest.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in New Delhi.
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The overall status was removed for Pfizer Investigational Site.
15 Jun '13
A location was updated in Muenster.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Hyderabad.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in New Delhi.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Taoyuan County.
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The overall status was removed for Pfizer Investigational Site.
15 May '13
A location was updated in Port Charlotte.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Seoul.
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The overall status was updated to "Terminated" at Pfizer Investigational Site.
A location was updated in Kaohsiung.
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The overall status was removed for Pfizer Investigational Site.
16 Apr '13
A location was updated in St. Louis.
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The overall status was removed for Pfizer Investigational Site.
16 Mar '13
A location was updated in Seoul.
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The overall status was removed for Pfizer Investigational Site.
16 Feb '13
A location was updated in Port Charlotte.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Golden Valley.
New
The overall status was updated to "Not yet recruiting" at Pfizer Investigational Site.
A location was updated in Robbinsdale.
New
The overall status was updated to "Not yet recruiting" at Pfizer Investigational Site.
A location was updated in St. Louis.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Bordeaux.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Paris CEDEX 13.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Taichung.
New
The overall status was removed for Pfizer Investigational Site.
15 Jan '13
A location was updated in Birmingham.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Birmingham.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Deerfield Beach.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Fort Lauderdale.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Detroit.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Sofia.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Pune.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in New Delhi.
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The overall status was removed for Pfizer Investigational Site.
3 Nov '12
A location was updated in Gyor.
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The overall status was removed for Pfizer Investigational Site.
29 Sep '12
A location was updated in Hershey.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Hummelstown.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Taipei.
New
The overall status was removed for Pfizer Investigational Site.
6 Sep '12
A location was updated in Pawtucket.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Providence.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Essen.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Muenchen.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Regensburg.
New
The overall status was removed for Pfizer Investigational Site.
14 Jul '12
A location was updated in Muenster.
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The overall status was removed for Pfizer Investigational Site.
19 Jun '12
A location was updated in Edmonton.
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The overall status was removed for Pfizer Investigational Site.
5 May '12
The Summary of Purpose was updated.
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The purpose of this study is to evaluate the safety and tolerability of PF-03049423 following multiple dose administration to subjects with ischemic stroke. The study will also evaluate the efficacy of PF-03049423, relative to placebo, in subjects with ischemic stroke following 90 days of therapy. The study will also explore the relationship between PF-03049423 concentration and blood pressure.
Old
The purpose this study is to evaluate the safety and tolerability of PF-03049423 following multiple dose administration to subjects with ischemic stroke. The study will also evaluate the efficacy of PF-03049423, relative to placebo, in subjects with ischemic stroke following 90 days of therapy. The study will also explore the relationship between PF-03049423 concentration and blood pressure.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Fort Wayne.
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The overall status was removed for Pfizer Investigational Site.
22 Mar '12
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Columbus.
New
The overall status was removed for Pfizer Investigational Site.
23 Feb '12
A location was updated in Boston.
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The overall status was removed for Pfizer Investigational Site.
20 Jan '12
A location was updated in Edmonton.
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The overall status was removed for Pfizer Investigational Site.
20 Dec '11
A location was updated in Birmingham.
New
The overall status was removed for Pfizer Investigational Site.
A location was updated in Birmingham.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Altenburg.
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The overall status was removed for Pfizer Investigational Site.
A location was updated in Essen.
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The overall status was removed for Pfizer Investigational Site.
9 Nov '11
A location was updated in Altenburg.
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The overall status was removed for Pfizer Investigational Site.
14 Oct '11
A location was updated in Muenster.
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The overall status was removed for Pfizer Investigational Site.