Structural Neuroplasticity Associated With Aerobic Treadmill Training in Geriatric Chronic Stroke Survivors

Completed

Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- women and men aged > 60 years
- first ever ischemic stroke at least prior 6 months
- all conventional inpatient and outpatient physical therapy completed
- residual hemiparetic gait disturbance adequate language and neurocognitive function to participate in exercise training and testing

Exclusion Criteria

- already performing > 20 minutes aerobic exercise 3 X/ week
- Alcohol consumption >2 oz liquor, or 2x 4oz glasses of wine, or 2x 12 oz cans of beer per day.
- Cardiac history of
1. unstable angina
2. recent (< 3 months) myocardial infarction
3. congestive heart failure (NYHA category II)
4. hemodynamically significant valvular dysfunction.
- Medical History:
1. recent hospitalization (<3 months) for severe medical disease
2. symptomatic peripheral arterial occlusive disease
3. orthopedic or chronic pain conditions restricting exercise
4. pulmonary or renal failure
5. active cancer
6. poorly controlled hypertension (>160/100) or diabetes mellitis (fasting glucose>180 mg/dl, HbA1C >10%)
- Neurological history of
1. dementia
2. receptive or global aphasia that confounds testing and training, operationally defined as unable to follow 2 point commands
3. cognitive deficits (other than dementia and aphasia, as above)
(e) non-stroke neuromuscular disorder restricting exercise (eg Parkinson's Syndrome) (f) untreated major depression
- exclusion criteria for MRI scanning (metal implants (e.g. pacemaker), claustrophobia, etc.)