The aim pf this prospective study is to investigate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in patients undergoing kidney transplantation.
Optimal intraoperative fluid management guided by central venous pressure (CVP), a traditional intravascular volume status indicator has been established to improve transplanted graft function during renal transplantation. Recently, stroke volume variation (SVV) and pulse pressure variation (PPV), dynamic preload indices derived from the arterial waveform are increasingly advocated as predictors of fluid responsiveness in anesthetized patients and critically ill patients. However, their usefulness in renal failure patients undergoing renal transplantation has not been investigated. Thus, the aims of this study is to investigate accuracy of SVV and PPV for predicting fluid responsiveness in patients undergoing kidney transplantation.
- Fluid loading Other
Intervention Desc: fluid loading was performed by using 7ml/kg of 6% hydroxyethyl starch within 10 min to all patients ARM 1: Kind: Experimental Label: SVV and PPV Description: SVV(stroke volume variation): recorded using the Flotrac/Vigileo system (Edwards Lifesciences) PPV(pulse pressure variation): recorded using philips Intelivue MP70 monitors (Philips Medical System) Intervention: Other: Fluid loading using HES 130/0.4; voluven; Fresenius Kabi; Stans, Switzerland
- Masking: Single Blind (Outcomes Assessor)
- Purpose: Diagnostic
- Endpoint: Efficacy Study
- Intervention: Single Group Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||stroke volume variation from Flo stroke volume variation from FloTrac/Vigileo system||within 5 minutes after fluid expansion||No|
|Primary||pulse pressure variation from philips Intelivue MP70 monitor||within 5 minutes after fluid expansion||No|