Stroke Treatment with Acute Reperfusion and Simvastatin "STARS07"


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

Patients older than 18 years with acute ischemic stroke (less than 12 hours from stroke onset); stroke involving the vascular territory of MCA-ACA-PCA; NIHSS score 4 to 22;previous modified Rankin Scale score of 1 or 0; patients not taking statins for the past six months.

Exclusion Criteria

Pregnancy or breastfeeding; clinical or radiological evidence on admission of intracranial hemorrhage, hemorrhagic infarction or tumor; seizures at the time of inclusion; complete or substantial recovery prior to randomization; patients with ipsilateral neurological deficit that may mask the evaluation of the current event;liver disease (AST or ALT more than twice upper normality limit); cardiogenic shock or relevant cardiac failure;patients with more than five times upper normality limit of CPK; myocardial infarction or any other thromboembolic event within the previous 30 days; active infection by the time of inclusion; documented hypersensibility to statins; drug abuse; expected short life-expectancy related to other systemic diseases.