Stroke Prevention in Reversible Ischemia Trial "SPIRIT"

Completed

Phase 3 Results

Results

53 major bleeding complications (27 intracranial, 17 fatal) during anticoagulant therapy vs. 6 on aspirin (3 intracranial, 1 fatal). "Anticoagulation therapy with an INR range of 3.0 to 4.5 in patients with cerebral ischemia of presumed arterial origin is not safe."