Stent-assisted Angioplasty of the Offending Intracranial Stenosis plus Optimal Medical Therapy versus Optimal Medical Therapy Alone "ASSIST II"


Phase N/A Results

Eligibility Criteria

Inclusion Criteria

?1 major atherosclerotic risk factors (arterial hypertension, hyperlipidemia, diabetes mellitus, hyperhomocystinemia and smoking); recurrent ischemic events (transient ischemic attack and/or stroke) attributed to an intracranial stenosis ? 50% on digital subtraction angiography (DSA); evidence of perfusion deficit at the territory referable to the target stenosis on CT-perfusion;diameters of the parent arteries are between 2.0 mm to 4.0 mm, and length of stenoses <=12 mm; modofied Rankin score (mRS) <=2 prior to last ischemic event.

Exclusion Criteria

Stenosis of non-atherosclerotic origin (for example, vasculitis, Moyamoya disease and fibromuscular dysplasia);intracranial hemorrhage and major ischemic stroke (NIHSS>=8)in the same hemisphere as the target lesion within 6 weeks;potential source of cardiac embolism; concurrent intracranial tumors, cerebral AVM and aneurysms; presence of a neurological illness that can confound the diagnosis of TIA or stroke; known contraindication to aspirin, clopidogrel, probucol, heparin, stainless steel, anesthesia, or x-ray contrast; uncorrectable bleeding diathesis; previous stenting of the target artery; positive pregnancy test; life expectancy <1 year because of other medical conditions; diameters of the parent arteries are <2.0 mm or > 4.0 mm, and length of stenoses >12 mm; mRS > 2 prior to last ischemic event; patients were not eligible if they could not cooperate with the study procedures or provide informed consent.