Skeletal Muscle Properties and the Metabolic Cost of Walking Post-stroke

Completed

Phase 2 Results

Eligibility Criteria

Inclusion Criteria

- age 18-80;
- stroke within past 6 months - 5 years;
- residual paresis in the lower extremity (LE) (Fugl-Meyer motor score <34);
- ability to sit unsupported for 30 sec;
- ability to walk at least 10 ft with maximum 1 person assist;
- self selected 10 meter gait speed < 0.8 m/s; and
- provision of informed consent.

Exclusion Criteria

- Unable to ambulate at least 150 feet prior to stroke, or experienced intermittent claudication while walking < 200 meters;
- history of congestive heart failure, unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during activities of daily living;
- History of chronic obstructive pulmonary disease or oxygen dependence;
- Preexisting neurological disorders, dementia or previous stroke;
- History of major head trauma;
- Legal blindness or severe visual impairment;
- history of significant psychiatric illness;
- Life expectancy <1 yr;
- Severe arthritis or orthopedic problems that limit passive range of motion (ROM);
- post-stroke depression (PHQ-9 10);
- History of deep vein thrombosis (DVT) or pulmonary embolism within 6 months;
- Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions;
- Severe hypertension with systolic >200 mmHg and diastolic >110 mmHg at rest;
- Previous or current enrollment in a clinical trial to enhance motor recovery;
- Presence of non-magnetic resonance (MR) compatible implants or devices, pregnancy or severe claustrophobia.