Silent Cerebral Infarcts After Carotid Endarterectomy Or Stenting And The Risk Of Cognitive Decline

Recruiting

Phase N/A Results N/A

Trial Description

To compare the frequency of new cerebral ischemic lesions after carotid endarterectomy (CEA) or carotid artery stenting (CAS) for symptomatic stenosis of the internal carotid artery, and to test their impact on cognitive function and quality of life.

Interventions

  • Endarterectomy, carotid (CEA)Procedure/Surgery
    Intervention Desc: Surgical therapy to remove atherosclerotic plaque in narrowed carotid arteries.
  • Stent, carotid Procedure/Surgery
    Intervention Desc: Intravascular procedure to maintain carotid artery patency

Trial Design

Multicenter substudy of a randomized controlled trial - ICSS.

Patient Involvement

Patients will be randomized to receive either carotid endarterectomy (CEA) or carotid artery stenting (CAS)

Outcomes

Type Measure Time Frame Safety Issue
Primary Detailed neuropsychological examination and Stroke-Specific Quality of Life Scale will be given in the week preceding the intervention, and at six months thereafter.
Secondary Stroke-Specific Quality of Life Scale at six months, and ischemic damage as assessed with MRI at one day and one month.

Sponsors

Netherlands Heart Foundation