The purpose of this study is to find the genes that increase the risk of developing an ischemic stroke using DNA samples collected from concordant (stroke-affected) sibling pairs.
Stroke is the third leading cause of death in the United States and a leading cause of acquired disability in adults. Each year, about 700,000 people experience stroke in the country. Ischemic stroke, which constitutes about 80 percent of all strokes, is a complex genetic disorder--the result of interactions between multiple genes and multiple environmental exposures. Genes affecting cholesterol, blood pressure, clotting, and other factors may increase the risk of ischemic stroke.
In this clinical study, investigators are studying groups of siblings in which at least two of the siblings have had an ischemic stroke. The goal of this multi-center study is to find the genes that increase the risk of developing an ischemic stroke.
To accomplish the aims of the study, researchers are using DNA samples collected from concordant (stroke-affected) sibling pairs to determine if there are regions in the human genome associated with ischemic stroke or that may harbor stroke susceptibility genes.
Two teaspoons of blood will be collected from each participant and submitted for genetic analysis. Understanding the genetic predisposition to stroke could have major benefits for public health.
- Observation: Family-Based
- Perspective: Prospective
- Sampling: Non-Probability Sample
in-patient or out-patient clinics, local community
Probands: Prior to enrollment, patients' medical records and test results will be reviewed by a study neurologist to confirm the diagnosis of ischemic stroke. Eligible patients will be classified by stroke subtype, according to the TOAST criteria. Probands will then mail invitations to participate in SWISS to their siblings.
Discordant Siblings: Persons who respond positively to the SWISS invitation will be given the QSVS test and a brief medical history via telephone interview. Patients who receive a QSVS score > 0 will be considered for inclusion in the "Concordant Siblings" group.
Concordant Siblings: Persons who respond positively to the SWISS invitation will have their medical records requested and reviewed by investigators in order to verify stroke diagnosis.
Once an eligible proband has at least one verified concordant sibling, blood will be collected from all enrolled family members for genetic analysis by a home health care agency.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Chromosomal regions correlated with ischemic stroke risk.|
Biospecimen Retention:Samples With DNA - Whole blood