Sex Differences in the Risk of Cardiovascular Diseases Associated With Diabetes

Active, not recruiting

Phase N/A Results N/A

Trial Description

To evaluate the risk of cardiovascular events associated with medication use for controlling blood glucose, blood pressure and cholesterol levels in men and women with diabetes treated in primary care

Detailed Description

The management and treatment of adult diabetes is far from optimal. The most recent report from the National Diabetes Audit showed that only one in three people with diabetes are achieving recommended standards for controlling blood glucose, blood pressure and cholesterol levels; and only three in five received basic care processes to reduce their risk of diabetes-related complications such as blindness, amputation and kidney disease. Women did 15% worse than men, which may explain some of the reported higher excess risk of coronary heart disease and stroke, consequent to diabetes in women than men. More efficient and equitable care in people with diabetes could lead to substantial cost savings, and would improve the lives of women and men currently living with diabetes.
The objective of this research isto evaluate the risk of cardiovascular events associated with medication use for controlling blood glucose, blood pressure and cholesterol levels in men and women with diabetes treated in primary care.

Conditions

Interventions

  • No intervention is given. Other
    Intervention Desc: This study is based on the analysis of linked electronic health records (CALIBER dataset)

Trial Design

  • Observation: Cohort
  • Perspective: Retrospective
  • Sampling: Non-Probability Sample

Trial Population

Patients in the CALIBER database who have diabetes, are included in the Clinical Practice Research Datalink (CPRD) and consented to data linkage.

Outcomes

Type Measure Time Frame Safety Issue
Primary First occurrence of cardiovascular disease 10 years No
Secondary Cardiovascular mortality 10 years No
Secondary All cause mortality 10 years No

Sponsors