Selenium and Ischemic Stroke Outcome

Not yet recruiting

Phase 0 Results N/A

Trial Description

Selenium is a trace element essential to human health.Selenium protection against cellular damage by oxygen radicals is accomplished through selenoproteins. Ischemic stroke is associated with the generation of oxygen free radicals resulting in a condition of oxidative stress. Supplementing stroke patients with antioxidant nutrients may improve survival.

Conditions

Interventions

  • Normal Saline Drug
    ARM 1: Kind: Experimental
    Label: normal saline
    Description: 40 cc normal saline stat and 20 cc daily for 5 days( in vials like selenase vial)
  • Selenium Drug
    Other Names: selenase
    Intervention Desc: 4 vials selenase stat and 2 vials daily for 5 days
    ARM 1: Kind: Experimental
    Label: selenium
    Description: vial selenium (selenase 500 microgr ) 2000 microgram stat and 1000 microgram daily for 5 days

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary National Institutes of Health Stroke Scale(NIHSS) up to 3 days Yes
Primary modified Rankin Scale (MRS) at day 5-8 Yes
Secondary Barthel index 3 months after discharge Yes

Sponsors